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DNA Polymerase alpha is essential for intracellular amplification of hepatitis B virus covalently closed circular DNA

26 Apr 2019

Abstract excerpt

Persistent hepatitis B virus (HBV) infection relies on the establishment and maintenance of covalently closed circular (ccc) DNA, a 3.2 kb episome that serves as a viral transcription template, in the nucleus of an infected hepatocyte. Although evidence suggests that cccDNA is the repair product of nucleocapsid associated relaxed circular (rc) DNA, the cellular DNA polymerases involving in repairing the...

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PMID: 31026293
DOI: 10.1371/journal.ppat.1007742

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