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The role of host DNA ligases in hepadnavirus covalently closed circular DNA formation

29 Dec 2017

Abstract excerpt

Hepadnavirus covalently closed circular (ccc) DNA is the bona fide viral transcription template, which plays a pivotal role in viral infection and persistence.Upon infection, the nonreplicative cccDNA is converted from the incoming and de novo synthesized viral genomic relaxed circular (rc) DNA, presumably through employment of the host cell's DNA repair mechanisms in the nucleus.The conversion of rcDNA into...

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PMID: 29287110
DOI: 10.1371/journal.ppat.1006784

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