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Correlation Between Genetic Abnormalities in Induced Pluripotent Stem Cell-Derivatives and Abnormal Tissue Formation in Tumorigenicity Tests.

Stem cells translational medicine - 27 May 2022

Yamamoto Takako, Sato Yoji, Yasuda Satoshi, Shikamura Masayuki, Tamura Takashi, Takenaka Chiemi, Takasu Naoko, Nomura Masaki, Dohi Hiromi, Takahashi Masayo, Mandai Michiko, Kanemura Yonehiro, Nakamura Masaya, Okano Hideyuki, Kawamata Shin

Abstract excerpt

Cell therapy using induced pluripotent stem cell (iPSC) derivatives may result in abnormal tissue generation because the cells undergo numerous cycles of mitosis before clinical application, potentially increasing the accumulation of genetic abnormalities. Therefore, genetic tests may predict abnormal tissue formation after transplantation. Here, we administered iPSC derivatives with or without single-nucleotide...

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Identifiers

PMID: 35445254
DOI: 10.1093/stcltm/szac014
PMCID: PMC9154342

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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