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Article

Transmission of tauopathy strains is independent of their isoform composition

7 Jan 2020

Abstract excerpt

The deposition of pathological tau is a common feature in several neurodegenerative tauopathies. Although equal ratios of tau isoforms with 3 (3R) and 4 (4R) microtubule-binding repeats are expressed in the adult human brain, the pathological tau from different tauopathies have distinct isoform compositions and cell type specificities. The underlying mechanisms of tauopathies are unknown, partially due to the...

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PMID: 31911587
DOI: 10.1038/s41467-019-13787-x

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