Article

Comparative Analysis of Primary (3R/4R) versus Secondary (3R + 4R) Tauopathy Strains in Rodent Models: A Systematic Review

2025-12-02

Abstract excerpt

<title>Abstract</title> <p>Background Tauopathies are a heterogeneous group of neurodegenerative disorders characterized by a pathological tau aggregation. Each disorder is defined by distinct isoform content (3R, 4R, or mixed 3R/4R), which dictates cell-type susceptibility, pathologic propagation, and clinical symptomatology. How these strains propagate in vivo will be critical to developing translational models...

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Literature Corpus work: b4b24f21-3845-5cb1-90dc-85f5293e2eb6
DOI: 10.21203/rs.3.rs-8090222/v1

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