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Article

Humanized APOE genotypes influence lifespan independently of tau aggregation in the P301S mouse model of tauopathy.

Acta neuropathologica communications - 19 Jun 2023

Williams Tristan, Bathe Tim, Vo Quan, Sacilotto Patricia, McFarland Karen, Ruiz Alejandra Jolie, Hery Gabriela P, Sullivan Patrick, Borchelt David R, Prokop Stefan, Chakrabarty Paramita

Abstract excerpt

Apolipoprotein (APOE) E4 isoform is a major risk factor of Alzheimer's disease and contributes to metabolic and neuropathological abnormalities during brain aging. To provide insights into whether APOE4 genotype is related to tau-associated neurodegeneration, we have generated human P301S mutant tau transgenic mice (PS19) that carry humanized APOE alleles (APOE2, APOE3 or APOE4). In aging mice that succumbed to...

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Identifiers

PMID: 37337279
DOI: 10.1186/s40478-023-01581-2
PMCID: PMC10280946

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