Article
53BP1 Enforces Distinct Pre- and Post-resection Blocks on Homologous Recombination.
Molecular cell - 2 Jan 2020
Callen Elsa, Zong Dali, Wu Wei, Wong Nancy, Stanlie Andre, Ishikawa Momoko, Pavani Raphael, Dumitrache Lavinia C, Byrum Andrea K, Mendez-Dorantes Carlos, Martinez Paula, Canela Andres, Maman Yaakov, Day Amanda, Kruhlak Michael J, Blasco Maria A, Stark Jeremy M, Mosammaparast Nima, McKinnon Peter J, Nussenzweig André
Abstract excerpt
53BP1 activity drives genome instability and lethality in BRCA1-deficient mice by inhibiting homologous recombination (HR). The anti-recombinogenic functions of 53BP1 require phosphorylation-dependent interactions with PTIP and RIF1/shieldin effector complexes. While RIF1/shieldin blocks 5'-3' nucleolytic processing of DNA ends, it remains unclear how PTIP antagonizes HR. Here, we show that mutation of the PTIP...
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