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Article

TOPBP1Dpb11 plays a conserved role in homologous recombination DNA repair through the coordinated recruitment of 53BP1Rad9

22 Feb 2017

Abstract excerpt

Genome maintenance and cancer suppression require homologous recombination (HR) DNA repair. In yeast and mammals, the scaffold protein TOPBP1Dpb11 has been implicated in HR, although its precise function and mechanism of action remain elusive. In this study, we show that yeast Dpb11 plays an antagonistic role in recombination control through regulated protein interactions. Dpb11 mediates opposing roles in DNA end...

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PMID: 28228534
DOI: 10.1083/jcb.201607031

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Related research

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TOPBP1Dpb11 plays a conserved role in homologous recombination DNA repair through the coordinated recruitment of 53BP1Rad9PMID 28228534Read ↗

Rad9/53BP1 promotes crossover recombination DNA repair by limiting the Sgs1 and Mph1 helicasesSemantic proximity Read ↗

53BP1 Enforces Distinct Pre- and Post-resection Blocks on Homologous Recombination.Semantic proximity Read ↗

BRCT Domain-containing Protein TopBP1 Functions in DNA Replication and Damage ResponseSemantic proximity Read ↗

H3K4 methylation by SETD1A/BOD1L facilitates RIF1-dependent NHEJSemantic proximity Read ↗

Dpb4 promotes resection of DNA double-strand breaks and checkpoint activation by acting in two different protein complexes.Semantic proximity Read ↗

BRCA1-Dependent and Independent Recruitment of PALB2–BRCA2–RAD51 in the DNA Damage Response and CancerSemantic proximity Read ↗

The unstructured C-terminal tail of yeast Dpb11 (human TopBP1) protein is dispensable for DNA replication and the S phase checkpoint but required for the G2/M checkpoint.Semantic proximity Read ↗

TopBP1 associates with NBS1 and is involved in homologous recombination repairSemantic proximity Read ↗

53BP1 mediates productive and mutagenic DNA repair through distinct phosphoprotein interactions.Semantic proximity Read ↗

Structure and function of the Rad9-binding region of the DNA-damage checkpoint adaptor TopBP1Semantic proximity Read ↗

Slx4 and Rtt107 control checkpoint signalling and DNA resection at double-strand breaks.Semantic proximity Read ↗

Functional interplay between the 53BP1-ortholog Rad9 and the Mre11 complex regulates resection, end-tethering and repair of a double-strand break.Semantic proximity Read ↗

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