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Article

Characterization of KIR+ NK cell subsets with a monoclonal antibody selectively recognizing KIR2DL1 and blocking the specific interaction with HLA-C.

HLA - 1 Aug 2022

Meazza Raffaella, Falco Michela, Canevali Paolo, Loiacono Fabrizio, Colomar-Carando Natalia, Muntasell Aura, Rea Anna, Mingari Maria Cristina, Locatelli Franco, Moretta Lorenzo, Lopez-Botet Miguel, Pende Daniela

Abstract excerpt

The phenotypic identification of different NK cell subsets allows more in-depth characterization of KIR repertoire and function, which are of potential interest in KIR and disease association studies. KIR genes are highly polymorphic, but a great homology exists among the various sequences and few monoclonal antibodies (mAbs) specifically recognize a single KIR. This is the case of HP-DM1 which was demonstrated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, MHC Class I

Share to HLA-C Antigens

Share to Killer Cells, Natural

Share to Receptors, KIR

Share to Receptors, KIR2DL1

Source

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Identifiers

PMID: 35439359
DOI: 10.1111/tan.14640
PMCID: PMC9543057

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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