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Article

A European Network of Paediatric Research at the European Medicines Agency (Enpr-EMA)

27 Nov 2011

Abstract excerpt

NK cells are an important component of host immune defense against malignancy and infection. NK cells are educated by MHC class I ligands to ensure self-tolerance while also promoting lytic competency against altered self and damaged self targets. However, the intracellular molecular events that culminate in tolerance and functional competency of educated NK cells remain undefined. Mice with germline deficiency...

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PMID: 22123735
DOI: 10.1136/archdischild-2011-300286

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