Article
Combined genotypic and phenotypic killer cell Ig-like receptor analyses reveal KIR2DL3 alleles displaying unexpected monoclonal antibody reactivity: identification of the amino acid residues critical for staining.
Journal of immunology (Baltimore, Md. : 1950) - 1 Jul 2010
Falco Michela, Romeo Elisa, Marcenaro Stefania, Martini Stefania, Vitale Massimo, Bottino Cristina, Mingari Maria Cristina, Moretta Lorenzo, Moretta Alessandro, Pende Daniela
Abstract excerpt
In humans, recent clinical and experimental data from hematopoietic stem cell transplantation revealed that donor-derived alloreactive NK cells exert a beneficial graft versus leukemia effect. The existence of donor-derived alloreactive NK cells can be predicted on the basis of donor killer cell Ig-like receptor (KIR) gene profile and HLA class I typing of both donor and recipient. Moreover, the size of the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.