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Article

Interaction between genetic predisposition, smoking, and dementia risk: a population-based cohort study.

Scientific reports - 21 Jun 2021

Zhang Na, Ranson Janice M, Zheng Zhi-Jie, Hannon Eilis, Zhou Zhenwei, Kong Xuejun, Llewellyn David J, King Daniel A, Huang Jie

Abstract excerpt

We evaluated whether the association between cigarette smoking and dementia risk is modified by genetic predisposition including apolipoprotein E (APOE) genotype and polygenic risk (excluding the APOE region). We included 193,198 UK Biobank participants aged 60-73 years without dementia at baseline. Of non-APOE-ε4 carriers, 0.89% (95% CI 0.73-1.08%) current smokers developed dementia compared with 0.49% (95% CI...

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Identifiers

PMID: 34155245
DOI: 10.1038/s41598-021-92304-x
PMCID: PMC8217565

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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