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Article

Theiler's murine encephalomyelitis virus induced phenotype switch of microglia in vitro.

Journal of neuroimmunology - 15 Nov 2012

Gerhauser I, Hansmann F, Puff C, Kumnok J, Schaudien D, Wewetzer K, Baumgärtner W

Abstract excerpt

The present in vitro study aimed to define the involvement of astrocytes and microglia in the initial inflammatory response of Theiler's murine encephalomyelitis (TME), a virus-induced mouse model of multiple sclerosis, and whether intralesional microglia exert pro- (M1) or anti-inflammatory (M2) effects following TME virus (TMEV) infection. Therefore astrocytes and microglia were purified from neonatal murine...

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PMID: 22967352
DOI: 10.1016/j.jneuroim.2012.07.018

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TNF

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