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Article

Mouse models of immune dysfunction: their neuroanatomical differences reflect their anxiety-behavioural phenotype.

Molecular psychiatry - 1 Jul 2022

Fernandes Darren J, Spring Shoshana, Corre Christina, Tu Andrew, Qiu Lily R, Hammill Christopher, Vousden Dulcie A, Spencer Noakes T Leigh, Nieman Brian J, Bowdish Dawn M E, Foster Jane A, Palmert Mark R, Lerch Jason P

Abstract excerpt

Extensive evidence supports the role of the immune system in modulating brain function and behaviour. However, past studies have revealed striking heterogeneity in behavioural phenotypes produced from immune system dysfunction. Using magnetic resonance imaging, we studied the neuroanatomical differences among 11 distinct genetically modified mouse lines (n = 371), each deficient in a different element of the...

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PMID: 35422470
DOI: 10.1038/s41380-022-01535-5
PMCID: PMC9205773

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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