Article
Functional changes in transcriptomes of the prefrontal cortex and hippocampus in a mouse model of anxiety.
Pharmacological reports : PR - 1 Jan 2011
Virok Dezso P, Kis Zoltán, Szegedi Viktor, Juhász Gábor, Zvara Agnes, Müller Géza, Lévay György, Hársing László G, Rajkó Róbert, Penke Botond, Janka Zoltán, Janáky Tamás, Puskás László G
Abstract excerpt
Anxiety is a multi-etiology disorder influenced by both genetic background and environment. To study the impact of a genetic predisposition, we developed a novel mouse model of anxiety using a combination of crossbreeding and behavioral selection. Comparison of the transcriptomes from the prefrontal cortex and hippocampus of anxious and control mice revealed that the numbers of significantly up- and...
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