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Article

Cellular and molecular mechanisms involved in the establishment of HIV-1 latency

1 Feb 2013

Abstract excerpt

Latently infected cells represent the major barrier to either a sterilizing or a functional HIV-1 cure. Multiple approaches to reactivation and depletion of the latent reservoir have been attempted clinically, but full depletion of this compartment remains a long-term goal. Compared to the mechanisms involved in the maintenance of HIV-1 latency and the pathways leading to viral reactivation, less is known about...

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PMID: 23375003
DOI: 10.1186/1742-4690-10-11

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