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The Molecular Basis for Human Immunodeficiency Virus Latency

17 Jul 2017

Abstract excerpt

Although potent combination antiretroviral therapy can effectively block viral replication in the host, human immunodeficiency virus (HIV) persists due to the existence of latent but replication-competent proviruses residing primarily in a very small population of resting memory CD4 + T cells. Viral latency is established when the expression of the autoregulatory viral trans-activating factor Tat is reduced to...

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PMID: 28715973
DOI: 10.1146/annurev-virology-101416-041646

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