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Article

Butyrate supplementation regulates expression of chromosome segregation 1‑like protein to reverse the genetic distortion caused by p53 mutations in colorectal cancer.

International journal of oncology - 1 Jun 2022

Chang Chun-Chao, Kao Wei-Yu, Liu Chih-Yi, Su Hui-Hsien, Kan Yu-An, Lin Pao-Ying, Ku Wei-Chi, Chang Kang-Wei, Yang Ruey-Neng, Huang Chi-Jung

Abstract excerpt

The chromosome segregation 1‑like (CSE1L) protein, which regulates cellular mitosis and apoptosis, was previously found to be overexpressed in colorectal cancer (CRC) cells harboring mutations. Therefore, regulating CSE1L expression may confer chemotherapeutic effects against CRC. The gut microflora can regulate gene expression in colonic cells. In particular, metabolites produced by the gut microflora, including...

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Identifiers

PMID: 35417036
DOI: 10.3892/ijo.2022.5354
PMCID: PMC9084551

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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