Article
CSE1L modulates Ras-induced cancer cell invasion: correlation of K-Ras mutation and CSE1L expression in colorectal cancer progression.
American journal of surgery - 1 Sept 2013
Jiang Ming-Chung, Yeh Chung-Min, Tai Cheng-Jeng, Chen Hung-Chang, Lin Shu-Hui, Su Tzu-Cheng, Shen Shing-Chuan, Lee Woan-Ruoh, Liao Ching-Fong, Li Li-Tzu, Lee Ching-Hsiao, Chen Ying-Chun, Yeh Kun-Tu, Chang Chun-Chao
Abstract excerpt
BACKGROUND: Ras plays an important role in colorectal cancer progression. CSE1L (chromosome segregation 1-like) gene maps to 20q13, a chromosomal region that correlates with colorectal cancer development. We investigated the association of CSE1L with Ras in colorectal cancer progression. METHODS: The effect of CSE1L on metastasis-stimulating activity of Ras was studied in an animal model with tumor cells...
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