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HDAC3 overexpression and colon cancer cell proliferation and differentiation

11 Sept 2007

Abstract excerpt

An immunohistochemical analysis of human colorectal adenocarcinomas showed that cancer cells express widely varying levels of HDAC3. The SW480 colon cancer cell line was found to express high levels of HDAC3 compared to other colon cancer cell lines. p21 was poorly induced in SW480 cells relative to the lower HDAC3-expressing HT-29 cells. RNAi-induced reduction of HDAC3 in SW480 cells increased their...

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Share to Epigenetics and DNA Methylation
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PMID: 17849419
DOI: 10.1002/mc.20373

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