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Article

p21 <sup>WAF1</sup> is required for butyrate-mediated growth inhibition of human colon cancer cells

9 Jun 1998

Abstract excerpt

A diet high in fiber is associated with a decreased incidence and growth of colon cancers. Butyrate, a four-carbon short-chain fatty acid product of fiber fermentation within the colon, appears to mediate these salutary effects. We sought to determine the molecular mechanism by which butyrate mediates growth inhibition of colonic cancer cells and thereby to elucidate the molecular link between a high-fiber diet...

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PMID: 9618491
DOI: 10.1073/pnas.95.12.6791

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p21 <sup>WAF1</sup> is required for butyrate-mediated growth inhibition of human colon cancer cellsPMID 9618491Read ↗

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Differential modulation of human (Caco-2) colon cancer cell line phenotype by short chain fatty acids.Semantic proximity Read ↗

Histone acetylation regulates p21<sup>WAF1</sup>expression in human colon cancer cell linesSemantic proximity Read ↗

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p21 Waf1/Cip1 can protect human colon carcinoma cells against p53-dependent and p53-independent apoptosis induced by natural chemopreventive and therapeutic agents.Semantic proximity Read ↗

Novel detection and differential utilization of a c-myc transcriptional block in colon cancer chemoprevention.Semantic proximity Read ↗

Butyrate supplementation regulates expression of chromosome segregation 1‑like protein to reverse the genetic distortion caused by p53 mutations in colorectal cancer.Semantic proximity Read ↗

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