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Article

Sodium butyrate inhibits cell growth and stimulates p21WAF1/CIP1 protein in human colonic adenocarcinoma cells independently of p53 status.

Nutrition and cancer - 1 Jan 2003

Kobayashi Hanako, Tan Er Mei, Fleming Sharon E

Abstract excerpt

Butyric acid, one of the short-chain fatty acids produced by microbial fermentation in the colon, exhibits antiproliferative activities in various cancer cell lines. The initial objective of the study was to assess whether the effect of sodium butyrate (NaB) on cell growth differed by p53 status of the cells. Four human colorectal adenocarcinoma cell lines were used: HT29 (p53 point mutation), Caco2 (p53...

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Identifiers

PMID: 14690797
DOI: 10.1207/S15327914NC4602_14

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Sodium butyrate inhibits cell growth and stimulates p21WAF1/CIP1 protein in human colonic adenocarcinoma cells independently of p53 status.PMID 14690797Read ↗

Butyrate Activates the WAF1/Cip1 Gene Promoter through Sp1 Sites in a p53-negative Human Colon Cancer Cell LineSemantic proximity Read ↗

p21 <sup>WAF1</sup> is required for butyrate-mediated growth inhibition of human colon cancer cellsSemantic proximity Read ↗

The effects of short-chain fatty acids on human colon cancer cell phenotype are associated with histone hyperacetylation.Semantic proximity Read ↗

p21 Waf1/Cip1 can protect human colon carcinoma cells against p53-dependent and p53-independent apoptosis induced by natural chemopreventive and therapeutic agents.Semantic proximity Read ↗

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Butyrate supplementation regulates expression of chromosome segregation 1‑like protein to reverse the genetic distortion caused by p53 mutations in colorectal cancer.Semantic proximity Read ↗

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