Checkpoint kinase 1 modulates sensitivity to cisplatin after spindle checkpoint activation in SW620 cells.

doi:10.1016/j.biocel.2009.11.011

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Article

Checkpoint kinase 1 modulates sensitivity to cisplatin after spindle checkpoint activation in SW620 cells.

The international journal of biochemistry & cell biology - 1 Feb 2010

Peralta-Sastre A, Manguan-Garcia C, de Luis A, Belda-Iniesta C, Moreno S, Perona R, Sanchez-Perez I

Abstract excerpt

Aneuploidy is a common feature of tumours that arise by errors in chromosome segregation during mitosis. The aim of this study was to evaluate possible signaling pathways involved in sensitization to chemotherapy in cells with chromosomal instability. We designed a screen using the fission yeast Squizossaccharomyces pombe, to isolate strains showing a phenotype of chromosome mis-segregation and higher sensitivity...

Topics

Aneuploidy
Apoptosis
Biomarkers
Bleomycin
Cell Line, Tumor
Checkpoint Kinase 1
Chromosome Segregation
Cisplatin
DNA Damage
Drug Resistance, Neoplasm
G2 Phase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Gene Expression Profiling

Humans

Mitosis

Mutation

Phenotype

Protein Kinases

RNA, Messenger

Source

Open in PubMed

Identifiers

PMID: 19931410
DOI: 10.1016/j.biocel.2009.11.011

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-19931410-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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