Article
The genomic landscape of nonsmall cell lung carcinoma in never smokers.
International journal of cancer - 1 Jun 2020
Boeckx Bram, Shahi Rajendra B, Smeets Dominiek, De Brakeleer Sylvia, Decoster Lore, Van Brussel Thomas, Galdermans Daniella, Vercauter Piet, Decoster Lynn, Alexander Patrick, Berchem Guy, Ocak Sebahat, Vuylsteke Peter, Deschepper Koen, Lambrechts Marc, Cappoen Nadia, Teugels Erik, Lambrechts Diether, De Greve Jacques
Abstract excerpt
Lung cancer is the number one cause of cancer-related death worldwide with cigarette smoking as its major risk factor. Although the incidence of lung cancer in never smokers is rising, this subgroup of patients is underrepresented in genomic studies of lung cancer. Here, we assembled a prospective cohort of 46 never-smoking, nonsmall cell lung cancer (NSCLC) patients and performed whole-exome and low-coverage...
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