The Genomic Landscape of Early-Stage Ovarian High-Grade Serous Carcinoma.

doi:10.1158/1078-0432.CCR-21-1643

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Article

The Genomic Landscape of Early-Stage Ovarian High-Grade Serous Carcinoma.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jul 2022

Cheng Zhao, Mirza Hasan, Ennis Darren P, Smith Philip, Morrill Gavarró Lena, Sokota Chishimba, Giannone Gaia, Goranova Theodora, Bradley Thomas, Piskorz Anna, Lockley Michelle, Kaur Baljeet, Singh Naveena, Tookman Laura A, Krell Jonathan, McDermott Jacqueline, Macintyre Geoffrey, Markowetz Florian, Brenton James D, McNeish Iain A

Abstract excerpt

PURPOSE: Ovarian high-grade serous carcinoma (HGSC) is usually diagnosed at late stage. We investigated whether late-stage HGSC has unique genomic characteristics consistent with acquisition of evolutionary advantage compared with early-stage tumors. EXPERIMENTAL DESIGN: We performed targeted next-generation sequencing and shallow whole-genome sequencing (sWGS) on pretreatment samples from 43 patients with FIGO...

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PMID: 35398881
DOI: 10.1158/1078-0432.CCR-21-1643
PMCID: PMC7612959

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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