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Histopathological and genetic features of mismatch repair‐deficient high‐grade prostate cancer

8 Apr 2022

Abstract excerpt

AIMS: Mismatch repair (MMR) deficiency is commonly caused by functional inactivation of MLH1, PMS2, MSH2 or MSH6. The morphological and molecular correlates of MMR deficiency have been extensively characterized in certain tumour types such as colorectal and endometrial adenocarcinoma. In contrast, the histological and molecular features of MMR-deficient prostate cancer remain incompletely described. In this...

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PMID: 35395112
DOI: 10.1111/his.14645

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