Article
High prevalence of mismatch repair deficiency in prostate cancers diagnosed in mismatch repair gene mutation carriers from the colon cancer family registry.
Familial cancer - 1 Dec 2014
Rosty Christophe, Walsh Michael D, Lindor Noralane M, Thibodeau Stephen N, Mundt Erin, Gallinger Steven, Aronson Melyssa, Pollett Aaron, Baron John A, Pearson Sally, Clendenning Mark, Walters Rhiannon J, Nagler Belinda N, Crawford William J, Young Joanne P, Winship Ingrid, Win Aung Ko, Hopper John L, Jenkins Mark A, Buchanan Daniel D
Abstract excerpt
The question of whether prostate cancer is part of the Lynch syndrome spectrum of tumors is unresolved. We investigated the mismatch repair (MMR) status and pathologic features of prostate cancers diagnosed in MMR gene mutation carriers. Prostate cancers (mean age at diagnosis = 62 ± SD = 8 years) from 32 MMR mutation carriers (23 MSH2, 5 MLH1 and 4 MSH6) enrolled in the Australasian, Mayo Clinic and Ontario...
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