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Mutational spectrum of DNA damage and mismatch repair genes in prostate cancer

4 Sept 2023

Abstract excerpt

Over the past few years, a number of studies have revealed that a significant number of men with prostate cancer had genetic defects in the DNA damage repair gene response and mismatch repair genes. Certain of these modifications, notably gene alterations known as homologous recombination (HRR) genes; PALB2, CHEK2 BRCA1, BRCA2, ATM, and genes for DNA mismatch repair (MMR); MLH1, MSH2, MSH6, and PMS2 are connected...

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PMID: 37732318
DOI: 10.3389/fgene.2023.1231536

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