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Article

Histologic patterns in prostatic adenocarcinoma are not predictive of mutations in the homologous recombination repair pathway.

Human pathology - 1 Feb 2024

Mahlow Jon, Barry Marc, Albertson Daniel J, Jo Yeon Jung, Balatico Michael, Seasor Tori, Gebrael Georges, Kumar Shruti A, Sayegh Nicolas, Tripathi Nishita, Agarwal Neeraj, Swami Umang, Sirohi Deepika

Abstract excerpt

Somatic or germline homologous recombination repair (HRR) pathway gene mutations are commonly detected in prostate cancer, especially in advanced disease, and are associated with response to poly (ADP-ribose) polymerase (PARP) inhibitors. In this study, we evaluated whether histological patterns are predictive of HRR pathway gene mutations. The study population comprised 130 patients with advanced prostate...

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PMID: 38278448
DOI: 10.1016/j.humpath.2024.01.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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