Article
A Family and a Genome-Wide Polygenic Risk Score Are Independently Associated With Stroke in a Population-Based Study.
Stroke - 1 Jul 2022
Hämmerle Michelle, Forer Lukas, Schönherr Sebastian, Peters Annette, Grallert Harald, Kronenberg Florian, Gieger Christian, Lamina Claudia
Abstract excerpt
BACKGROUND: Positive family history and genetic risk scores have been shown to independently capture those individuals with high risk for stroke. The aim of our study was to evaluate the amount of shared information between family history and genetic risk and to investigate their combined effect on the association with prevalent and incident stroke cases. METHODS: We obtained a family risk score (FamRS), weighted...
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