Article
Genome-Wide Polygenic Score and the Risk of Ischemic Stroke in a Prospective Cohort: The Hisayama Study.
Stroke - 1 Mar 2020
Hachiya Tsuyoshi, Hata Jun, Hirakawa Yoichiro, Yoshida Daigo, Furuta Yoshihiko, Kitazono Takanari, Shimizu Atsushi, Ninomiya Toshiharu
Abstract excerpt
Background and Purpose- Environmental and genetic factors contribute to the development of ischemic stroke (IS). We recently developed a genome-wide polygenic risk score (PRS) for IS using case-control datasets from 4 large-scale observational studies conducted in Japan. Our objective in the present study was to confirm the association between the PRS and the risk of IS with data from an independent prospective...
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