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Article

Genomic risk score offers predictive performance comparable to clinical risk factors for ischaemic stroke.

Nature communications - 20 Dec 2019

Abraham Gad, Malik Rainer, Yonova-Doing Ekaterina, Salim Agus, Wang Tingting, Danesh John, Butterworth Adam S, Howson Joanna M M, Inouye Michael, Dichgans Martin

Abstract excerpt

Recent genome-wide association studies in stroke have enabled the generation of genomic risk scores (GRS) but their predictive power has been modest compared to established stroke risk factors. Here, using a meta-scoring approach, we develop a metaGRS for ischaemic stroke (IS) and analyse this score in the UK Biobank (n = 395,393; 3075 IS events by age 75). The metaGRS hazard ratio for IS (1.26, 95% CI 1.22-1.31...

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Identifiers

PMID: 31862893
DOI: 10.1038/s41467-019-13848-1
PMCID: PMC6925280

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