Article
Altered propionate metabolism contributes to tumour progression and aggressiveness.
Nature metabolism - 1 Apr 2022
Gomes Ana P, Ilter Didem, Low Vivien, Drapela Stanislav, Schild Tanya, Mullarky Edouard, Han Julie, Elia Ilaria, Broekaert Dorien, Rosenzweig Adam, Nagiec Michal, Nunes Joana B, Schaffer Bethany E, Mutvei Anders P, Asara John M, Cantley Lewis C, Fendt Sarah-Maria, Blenis John
Abstract excerpt
The alteration of metabolic pathways is a critical strategy for cancer cells to attain the traits necessary for metastasis in disease progression. Here, we find that dysregulation of propionate metabolism produces a pro-aggressive signature in breast and lung cancer cells, increasing their metastatic potential. This occurs through the downregulation of methylmalonyl coenzyme A epimerase (MCEE), mediated by an...
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