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Article

Propionate metabolism is dysregulated in non-small cell lung cancer patients and EGFR-mutant drug-tolerant persister cells.

Scientific reports - 18 Mar 2026

Parang Bobak, Yoffe Liron, Khan Rabia, Li Zhongchi, Nagiec Michal J, Gardner Eric E, Shieh Yiwey, Heise Rachel S, Saxena Ashish, Altorki Nasser, Blenis John

Abstract excerpt

Recent studies show that genetic sequencing can not fully explain drug resistance in non-small cell lung cancer (NSCLC), suggesting undiscovered non-genetic mechanisms that can enable cancer cell survival. Propionate metabolism is the pathway by which odd-chain fatty acids, branched chain amino acids, and cholesterol are metabolized. We have previously shown that methylmalonic acid (MMA), a byproduct of...

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Share to Carcinoma, Non-Small-Cell Lung
Share to Cell Line, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Neoplasm

Share to Epithelial-Mesenchymal Transition

Share to ErbB Receptors

Share to Gene Expression Regulation, Neoplastic

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Source

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Identifiers

PMID: 41851194
DOI: 10.1038/s41598-026-44451-2
PMCID: PMC13136305

Genes

MMAB
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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Propionate metabolism is dysregulated in non-small cell lung cancer patients and EGFR-mutant drug-tolerant persister cells.PMID 41851194Read ↗

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