Article

Propionate metabolism dysregulation promotes drug-tolerant persister cell survival in non-small cell lung cancer

2025-10-15

Abstract excerpt

Recent studies show that genetic sequencing can not fully explain drug resistance in non-small cell lung cancer (NSCLC), suggesting undiscovered non-genetic mechanisms that can enable cancer cell survival. Propionate metabolism is the pathway by which odd-chain fatty acids, branched chain amino acids, and cholesterol are metabolized. We have previously shown that methylmalonic acid (MMA), a byproduct of propionate...

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Literature Corpus work: 6c55d552-641f-5853-b968-0551b4b0ba0a
DOI: 10.1101/2025.10.15.682658

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