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Co-targeting an AMPK–MAPK axis reprograms fibroblasts and suppresses PDAC

2026-03-18

Abstract excerpt

<h4>SUMMARY</h4> Pancreatic ductal adenocarcinoma (PDAC) is a fatal cancer characterized by limited therapeutic options and a highly treatment-resistant tumor microenvironment. Beyond tumor-intrinsic genetic alterations, growing evidence indicates that host–microbiome interactions influence cancer progression through microbial metabolites. However, how microbiome-derived metabolites influence oncogenic signaling...

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Literature Corpus work
bcfe83ac-8674-5da2-ba0b-0ae71eaa8c27
DOI
10.64898/2026.03.16.711738
Open publication

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Co-targeting an AMPK–MAPK axis reprograms fibroblasts and suppresses PDACDOI 10.64898/2026.03.16.711738
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