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Tumor–stromal metabolic crosstalk in pancreatic cancer

26 May 2025

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with a dire prognosis. Standard-of-care chemotherapy regimens offer marginal survival benefit and carry risk of severe toxicity, while immunotherapy approaches have uniformly failed in clinical trials. Extensive desmoplasia in the PDAC tumor microenvironment (TME) disrupts blood flow to and from the tumor, thereby creating a nutrient-depleted,...

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PMID: 40425415
DOI: 10.1016/j.tcb.2025.04.007

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