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Article

An early-onset specific polygenic risk score optimizes age-based risk estimate and stratification of prostate cancer: population-based cohort study.

Journal of translational medicine - 17 Apr 2024

Cheng Yifei, Wu Lang, Xin Junyi, Ben Shuai, Chen Silu, Li Huiqin, Zhao Lingyan, Wang Meilin, Cheng Gong, Du Mulong

Abstract excerpt

BACKGROUND: Early-onset prostate cancer (EOPC, ≤ 55 years) has a unique clinical entity harboring high genetic risk, but the majority of EOPC patients still substantial opportunity to be early-detected thus suffering an unfavorable prognosis. A refined understanding of age-based polygenic risk score (PRS) for prostate cancer (PCa) would be essential for personalized risk stratification. METHODS: We included...

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Identifiers

PMID: 38632662
DOI: 10.1186/s12967-024-05190-y
PMCID: PMC11025178

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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