Trade-off between reducing mutational accumulation and increasing commitment to differentiation determines tissue organization.

Abstract excerpt

Species-specific differences control cancer risk across orders of magnitude variation in body size and lifespan, e.g., by varying the copy numbers of tumor suppressor genes. It is unclear, however, how different tissues within an organism can control somatic evolution despite being subject to markedly different constraints, but sharing the same genome. Hierarchical differentiation, characteristic of self-renewing...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cell Differentiation
• Share to Clonal Evolution