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Article

A compartment size-dependent selective threshold limits mutation accumulation in hierarchical tissues.

Proceedings of the National Academy of Sciences of the United States of America - 21 Jan 2020

Grajzel Dániel, Derényi Imre, Szöllősi Gergely J

Abstract excerpt

Cancer is a genetic disease fueled by somatic evolution. Hierarchical tissue organization can slow somatic evolution by two qualitatively different mechanisms: by cell differentiation along the hierarchy "washing out" harmful mutations and by limiting the number of cell divisions required to maintain a tissue. Here we explore the effects of compartment size on somatic evolution in hierarchical tissues by...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31907322
DOI: 10.1073/pnas.1913104117
PMCID: PMC6983402

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