Article

A compartment size dependent selective threshold limits mutation accumulation in hierarchical tissues

2019-07-31

Abstract excerpt

Cancer is a genetic disease fueled by somatic evolution. Hierarchical tissue organization can slow somatic evolution by two qualitatively different mechanisms: by cell differentiation along the hierarchy "washing out" harmful mutations (Nowak et al. 2003, Werner et al. 2013) and by limiting the number of cell divisions required to maintain a tissue (Derenyi and Szollosi 2017). Here we explore the effects of compar...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1049ffce-f22a-5fda-8d89-595efa89c15b
DOI: 10.1101/719575

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A compartment size dependent selective threshold limits mutation accumulation in hierarchical tissuesDOI 10.1101/719575Read

A compartment size-dependent selective threshold limits mutation accumulation in hierarchical tissues.Semantic proximity Read

Trade-off between reducing mutational accumulation and increasing commitment to differentiation determines tissue organizationSemantic proximity Read

Trade-off between reducing mutational accumulation and increasing commitment to differentiation determines tissue organization.Semantic proximity Read

A deterministic model for the occurrence and dynamics of multiple mutations in hierarchically organized tissues.Semantic proximity Read

Somatic selection for and against cancer.Semantic proximity Read

Hierarchical tissue organization as a general mechanism to limit the accumulation of somatic mutationsSemantic proximity Read

Optimizing homeostatic cell renewal in hierarchical tissues.Semantic proximity Read

Hierarchical tissue organization as a general mechanism to limit the accumulation of somatic mutations.Semantic proximity Read

Hierarchical tissue structure creates history-dependent barriers to clonal invasionSemantic proximity Read

A modelling framework for cancer ecology and evolution.Semantic proximity Read

Local regulation of homeostasis favors chromosomal instability.Semantic proximity Read

Dynamics of mutant cells in hierarchical organized tissues.Semantic proximity Read