Article

Hierarchical tissue organization as a general mechanism to limit the accumulation of somatic mutations

2017-01-04

Abstract excerpt

How can tissues generate large numbers of cells, yet keep the divisional load (the number of divisions along cell lineages) low in order to curtail the accumulation of somatic mutations and reduce the risk of cancer? To answer the question we consider a general model of hierarchically organized self-renewing tissues and show that the lifetime divisional load of such a tissue is independent of the details of the ce...

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Literature Corpus work: 0b773bf9-79fa-58e3-a4f3-cd979c9e8c47
DOI: 10.1101/098129

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