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Article

Pathways to tumorigenesis--modeling mutation acquisition in stem cells and their progeny.

Neoplasia (New York, N.Y.) - 1 Nov 2008

Ashkenazi Rina, Gentry Sara N, Jackson Trachette L

Abstract excerpt

Most adult tissues consist of stem cells, progenitors, and mature cells, and this hierarchical architecture may play an important role in the multistep process of carcinogenesis. Here, we develop and discuss the important predictions of a simple mathematical model of cancer initiation and early progression within a hierarchically structured tissue. This work presents a model that incorporates both the sequential...

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Identifiers

PMID: 18953426
DOI: 10.1593/neo.08572
PMCID: PMC2570593

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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