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Article

Hierarchical tissue organization as a general mechanism to limit the accumulation of somatic mutations.

Nature communications - 23 Feb 2017

Derényi Imre, Szöllősi Gergely J

Abstract excerpt

How can tissues generate large numbers of cells, yet keep the divisional load (the number of divisions along cell lineages) low in order to curtail the accumulation of somatic mutations and reduce the risk of cancer? To answer the question we consider a general model of hierarchically organized self-renewing tissues and show that the lifetime divisional load of such a tissue is independent of the details of the...

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Identifiers

PMID: 28230094
DOI: 10.1038/ncomms14545
PMCID: PMC5331224

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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