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SQSTM1/p62-Directed Metabolic Reprogramming Is Essential for Normal Neurodifferentiation

28 Feb 2019

Abstract excerpt

Neurodegenerative disorders are an increasingly common and irreversible burden on society, often affecting the aging population, but their etiology and disease mechanisms are poorly understood. Studying monogenic neurodegenerative diseases with known genetic cause provides an opportunity to understand cellular mechanisms also affected in more complex disorders. We recently reported that loss-of-function mutations...

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PMID: 30827875
DOI: 10.1016/j.stemcr.2019.01.023

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