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Article

Molecular landscape of pediatric type IDH wildtype, H3 wildtype hemispheric glioblastomas.

Laboratory investigation; a journal of technical methods and pathology - 1 Jul 2022

Hong Liang, Shi Zhi-Feng, Li Kay Ka-Wai, Wang Wei-Wei, Yang Rui Ryan, Kwan Johnny Sheung-Him, Chen Hong, Li Fang-Cheng, Liu Xian-Zhi, Chan Danny Tat-Ming, Li Wen-Cai, Zhang Zhen-Yu, Mao Ying, Ng Ho-Keung

Abstract excerpt

The WHO (2021) Classification classified a group of pediatric-type high-grade gliomas as IDH wildtype, H3 wildtype but as of currently, they are characterized only by negative molecular features of IDH and H3. We recruited 35 cases of pediatric IDH wildtype and H3 wildtype hemispheric glioblastomas. We evaluated them with genome-wide methylation profiling, targeted sequencing, RNAseq, TERT promoter sequencing,...

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PMID: 35332262
DOI: 10.1038/s41374-022-00769-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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