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Article

Molecular landscape of IDH-wild-type, H3-wild-type glioblastomas of adolescents and young adults.

Neuropathology and applied neurobiology - 1 Jun 2022

Shi Zhi-Feng, Li Kay Ka-Wai, Huang Queenie Jun-Qi, Wang Wei-Wei, Kwan Johnny Sheung-Him, Chen Hong, Liu Xiang-Zhi, Li Wen-Cai, Chan Danny Tat-Ming, Zhang Zhen-Yu, Mao Ying, Ng Ho-Keung

Abstract excerpt

OBJECTIVE: We aimed to characterise glioblastomas of adolescents and young adults (AYAs) that were isocitrate dehydrogenase (IDH) wild type (wt) and H3wt. MATERIALS AND METHODS: Fifty such patients (aged 16-32) were studied by methylation profiling, targeted sequencing and targeted RNA-seq. RESULTS: Tumours predominantly clustered into three methylation classes according to the terminology of Capper et al....

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PMID: 35191072
DOI: 10.1111/nan.12802

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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