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Article

Integrated analysis of pediatric glioblastoma reveals a subset of biologically favorable tumors with associated molecular prognostic markers.

Acta neuropathologica - 1 May 2015

Korshunov Andrey, Ryzhova Marina, Hovestadt Volker, Bender Sebastian, Sturm Dominik, Capper David, Meyer Jochen, Schrimpf Daniel, Kool Marcel, Northcott Paul A, Zheludkova Olga, Milde Till, Witt Olaf, Kulozik Andreas E, Reifenberger Guido, Jabado Nada, Perry Arie, Lichter Peter, von Deimling Andreas, Pfister Stefan M, Jones David T W

Abstract excerpt

Pediatric glioblastoma (pedGBM) is amongst the most common malignant brain tumors of childhood and carries a dismal prognosis. In contrast to adult GBM, few molecular prognostic markers for the pediatric counterpart have been established. We, therefore, investigated the prognostic significance of genomic and epigenetic alterations through molecular analysis of 202 pedGBM (1-18 years) with comprehensive clinical...

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Astrocytoma
Brain Neoplasms
Cell Transformation, Neoplastic
Epigenomics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

In Situ Hybridization, Fluorescence

Neoplasm Grading

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Identifiers

PMID: 25752754
DOI: 10.1007/s00401-015-1405-4

Genes

BRAF
IDH1
MGMT

Variants

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