Article
Integrated high-resolution copy number and histomolecular analysis of diffuse hemispheric glioma, H3 G34-mutant reveals universal TP53 abnormalities.
Brain pathology (Zurich, Switzerland) - 1 Jul 2026
Trejo-Lopez Jorge A, Mendoza Cinthya Zepeda, Kollmeyer Thomas M, Drucker Kristen L, Pazdernik Vanessa M, Decker Paul A, Praska Corinne E, Hardcastle Jayson, Smoley Stephanie, Isaacson Matthew, Gandham Mallika, Dasari Surendra, Raghunathan Aditya, Giannini Caterina, Zheng Gang, Wagner Aaron, Lopes M Beatriz, Fung Kar-Ming A, Peterson JoElle G, Rivera Andreana L, Rossi Christopher, Walsh Meggen A, Abdullaev Zied, Aldape Kenneth, Quezado Martha, Pratt Drew, Cimino Patrick Joseph, Jenkins Robert B, Ida Cristiane M
Abstract excerpt
Diffuse hemispheric glioma, H3 G34-mutant (DHG-H3 G34) has been primarily molecularly characterized by methylation profiling and sequencing studies. We describe an integrated histomolecular evaluation including high-resolution copy number profiling of a series of 60 DHG-H3 G34 to further our understanding of the spectrum of genetic changes associated with this tumor type. Cases were clinically tested using an...
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