Pediatric H3 G34-mutant diffuse hemispheric glioma: clinical, imaging and molecular prognostic factors, MGMT expression, and temozolomide response.

doi:10.1007/s00401-026-02992-w

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Article

Pediatric H3 G34-mutant diffuse hemispheric glioma: clinical, imaging and molecular prognostic factors, MGMT expression, and temozolomide response.

Acta neuropathologica - 2 Mar 2026

Tlais Dana, Zhang Qunyu, Roach Jordan T, Tinkle Christopher L, Lin Tong, Li Xiaoyu, Mostafa Ayatullah, Moreira Daniel C, McNall-Knapp Rene Y, Rush Sarah Z, Le Brian H, Sinno Sara, Ramnarayan Apeksha, Ginn Kevin F, Partap Sonia, Onar-Thomas Arzu, Furtado Larissa V, Bag Asim K, Chiang Jason

Abstract excerpt

Previous studies have demonstrated poor outcomes in pediatric patients with H3 G34-mutant diffuse hemispheric glioma (DHG). However, the biological basis for this therapeutic resistance remains poorly understood. Furthermore, the effectiveness of temozolomide (TMZ) and the role of surgery in pediatric patients remain uncertain. Therefore, we performed a multi-institutional retrospective analysis of the clinical,...

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Identifiers

PMID: 41770225
DOI: 10.1007/s00401-026-02992-w
PMCID: PMC12953265

Genes

MGMT
PDGFRA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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